Institute for Systems Biology is a private research organization focused on application of system-pharmacology modeling to different stages of drug research and development.
Our approach enables us to reconstruct the effects of taking medication in terms of clinically measured biomarkers and end-points, predict the efficacy of a drug in humans on the basis of data obtained in animals, search for optimal combinational therapies, describe biotechnological processes, and more.
Population PK/PD approach
The modeling of pharmacokinetics and pharmacodynamics (PK/PD) was historically the first mathematical approach used for drug research and development.
Physiologically based pharmacokinetics (PBPK)
Physiologically based pharmacokinetics is a more mechanistic and physiologically approved way to describe drug dynamics.