In the Institute for Systems Biology SPb we have been developing kinetic models of E. coli metabolism for the last several years. Thus, we had made the first steps in this field in the 2000-2002 years, when the initial kinetic models of glycolysis, TCA cycle and biosynthesis of basic biochemical building blocks (such as amino acids, purine and pyrimidine nucleotides) had been developed. Further elaboration allowed us to increase our activity in the understanding of E. coli metabolism functioning and expanded a range of metabolic pathways  which were taken into model account. By the present time we have developed kinetic models of more then 30 E. coli biochemical pathways and regulatory systems.

In this section of the website we represent several materials related to the E. coli metabolism modeling. Of course, it is a brief and incomplete description. However, we tried to stress an attention on the most obvious and interesting results of this large-scale modeling project. All these results are urged to accentuate the importance of systems biology modeling approaches for the investigation of the metabolism functioning and regulation.

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