AIM OF THE PROJECT: To develop database of automatically generated kinetic models corresponding to all pathways displayed in KEGG database.

OUR APPROACH

1. Development of Kinetic Models Database (KMD) initially using KEGG pathways.
2. All automatically generated models satisfy following requirements:
   • contain physiologically based input and output fluxes;
   • rate equations use mass action law;
   • kinetic parameters are automatically generated in physiological range;
   • presence of stable steady state.
3. All kinetic models available in two formats, both SLV and SBML.

RESULTS

• KMD consisting of about 19000 models has been developed.
• Rate equations of all models are in accordance to mass action law. All kinetic parameters are in the physiological range.
• Each model has stable steady state.