Clavulanic acid is an important component of a number of antibiotics. Main method of this compound production is a biotechnological synthesis using strains of Streptomyces clavuligerus. This gram-positive bacteria has a specific metabolic pathway leading to biosynthetic  production of clavulanic acid and other related beta-lactam antibiotics from arginine and glicerol-3-phosphate. Actually, such peculiarity of Streptomyces clavuligerus notices attention to the problem of strain improvement of this bacteria.

AIM OF THE PROJECT: search and collection of available experimental data characterizing biochemical properties of Streptomyces clavuligerus strains and an offer of strain improvement program based on predictions of the kinetic model of Streptomyces clavuligerus metabolism developed.

MAIN RESULTS

	Result 1. Kinetic model of the clavulanic acid biosynthesis in Streptomyces clavuligerus has been developed.
	Result 2. Based on the prediction on the kinetic model possible gene targets for strain improvement program have been identified.