The research of signal transduction pathways is one of the most popular directions in the contemporary biochemistry and molecular biology. Great number of scientific tasks is connected anyhow with signal transduction pathways. The action of hormones and several drugs, apoptosis, blood coagulation, cell differentiation, muscular contraction – that is only very small part, where researchers have to study in the more or less degree such kind of biochemical systems. Certain progress was outlined in this sphere recently. Thus, a lot of signal transduction pathways have already perfectly reconstructed – from source to target. Moreover, great number of quantitative experimental data, characterizing the dynamics of individual processes has been accumulated. The role of systems biology is to integrate all this information in to single whole, to analyze it and apply for various tasks solution, including applied ones (new drugs development and drug action investigation). In our group kinetic modeling is used as such integrative method that allows working with the widest diapason of experimental data. Moreover, we are able to research time dependence of signal expansion and to model very complex additive effects, when appearance and expansion of signal were influenced by several factors simultaneously.